SCHEMBL7322697

CC(OC(=O)c1ccccc1)OC(=O)C(CNC(=O)[C@H](CCCCN)NS(C)(=O)=O)CC1(C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)CCCC1

nearest known ligand 0.77

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	ECE1	P42892	4/20	0.77

▸	ACE	P12821	3/20	0.77

▸	MME	P08473	3/20	0.77

▸	NPPA	P01160	1/20	0.77

▸	ITGB3	P05106	1/20	0.38

▸	ITGA2B	P08514	1/20	0.38

▸	CPB2	Q96IY4	2/20	0.37

▸	ITGB1	P05556	4/20	0.36

▸	ITGA4	P13612	4/20	0.36

▸	MMP1	P03956	1/20	0.36

▸	GRIA1	P42261	1/20	0.36

▸	OPRM1	P35372	1/20	0.36

▸	OPRD1	P41143	1/20	0.36

▸	OPRK1	P41145	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10471733	1.00	ECE1 (0.77)	ECE1ACEMMENPPAITGB3
SCHEMBL10471734	1.00	ECE1 (0.77)	ECE1ACEMMENPPAITGB3
Sampatrilat SCHEMBL7301333	0.88	ECE1 (1.00)	ECE1ACEMMENPPAITGB3
Sampatrilat SCHEMBL49066	0.88	ECE1 (1.00)	ECE1ACEMMENPPAITGB3
Sampatrilat SCHEMBL4567110	0.88	ECE1 (1.00)	ECE1ACEMMENPPAITGB3
SCHEMBL7294367	0.83	ACE (0.91)	ECE1ACEMMENPPAITGB3
SCHEMBL7302871	0.81	MME (0.82)	ECE1ACEMMENPPAITGB3
SCHEMBL7302883	0.81	MME (0.82)	ECE1ACEMMENPPAITGB3
SCHEMBL9755064	0.78	MME (0.81)	ECE1ACEMMENPPAITGB1
SCHEMBL6441043	0.78	ACE (0.81)	ECE1ACEMMENPPAITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0358398-A1	Cycloalkyl-substituted glutaramide antihypertensive agents	Pfizer Limited (GB)	1990-03-14	—	—	EP	disclosed