SCHEMBL9691613

SCHEMBL9691613

COC(=O)OC1=C(C)NC(C)=C(OC(=O)O)C1c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.49
CACNA1F O60840 1/20 0.48
CACNA1D Q01668 1/20 0.48
CACNA1S Q13698 1/20 0.48
CACNA1C Q13936 1/20 0.48
KDM4E B2RXH2 6/20 0.41
HSD17B10 Q99714 5/20 0.41
ALDH1A1 P00352 5/20 0.41
HTT P42858 3/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TSHR P16473 3/20 0.39
HPGD P15428 3/20 0.39
MAPT P10636 3/20 0.39
KMT2A Q03164 3/20 0.39
POLB P06746 3/20 0.39
GAA P10253 2/20 0.39
MEN1 O00255 2/20 0.39
MAPK1 P28482 1/20 0.39
CACNA1B Q00975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10786897 0.96 ADORA3 (0.52) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9689715 0.89 ADORA3 (0.49) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL6963058 0.88 CACNA1F (0.49) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL11203237 0.88 CACNA1C (0.48) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9689619 0.86 ADORA3 (0.47) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10920209 0.83 CACNA1F (0.45) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10770890 0.83 ADORA3 (0.44) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10782467 0.83 ALDH1A1 (0.50) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10374975 0.83 ALDH1A1 (0.46) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7322941 0.82 ADORA3 (0.58) ADORA3CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0071819-B2 DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION BAYER AG (DE) 1992-06-10 EP disclosed
EP-0071819-B1 DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION BAYER AG (DE) 1987-04-22 EP disclosed
EP-0071819-A1 Dihydropyridines with a positive inotropic activity, their use in pharmaceutical preparations, and processes for their preparation BAYER AG (DE) 1983-02-16 EP disclosed