Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | MFN2 | O95140 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322944 | 1.00 | CTSK (0.50) | CTSKMFN2EPHX1KDM4EALDH1A1 | |
| SCHEMBL23022877 | 0.79 | CTSK (0.47) | CTSKKDM4EALDH1A1MAPTSLC6A2 | |
| SCHEMBL356569 | 0.76 | CHRM2 (0.37) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL13424200 | 0.76 | CALM1 (0.43) | MFN2KDM4EALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL7326227 | 0.75 | SLC6A4 (0.45) | CTSKKDM4EALDH1A1MAPTSLC6A2 | |
| SCHEMBL12808408 | 0.75 | MAPT (0.50) | MFN2EPHX1MAPTEPHX2 | |
| SCHEMBL356099 | 0.74 | CHRM2 (0.38) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL18440290 | 0.73 | SLC6A2 (0.48) | KDM4EALDH1A1MAPTSLC6A2SLC6A4 | |
| SCHEMBL12282055 | 0.73 | CPB1 (0.57) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL13568632 | 0.73 | SLC18A3 (0.49) | MFN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262431-A | Treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0275482-B1 | PROLINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5112847-A | PROLINAL DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROLYL ENDOPEPTIDASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| US-4983624-A | Anemia | ONO PHARMACEUTICAL CO., LTD (JP) | 1991-01-08 | — | — | US | disclosed |
| EP-0275482-A2 | Proline derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-07-27 | — | — | EP | disclosed |