Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328436 | 0.94 | CHRNA7 (0.37) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7362613 | 0.92 | CHRNA7 (0.35) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL7324063 | 0.85 | CHRNA7 (0.39) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL13617347 | 0.85 | CHRNA7 (0.39) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL28703379 | 0.83 | CHRNA7 (0.38) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL26462625 | 0.78 | GNAI3 (0.41) | CHRM2CHRM1 | |
| SCHEMBL415807 | 0.76 | CHRNA7 (0.42) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL18268169 | 0.76 | CHRNA7 (0.42) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL18268167 | 0.76 | CHRNA7 (0.42) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 | |
| SCHEMBL28682845 | 0.74 | ALOX5 (0.41) | CHRNA7CHRM2CHRNA4CHRM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625979-A1 | AZABRICYCLIC COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993015073-A1 | AZABRICYCLIC COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |