Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323702 | 1.00 | CHRM2 (0.31) | CHRM2CHRM1CHRM3TLR4TLR2 | |
| SCHEMBL1710562 | 0.77 | TLR4 (0.34) | TLR4TLR2 | |
| SCHEMBL1710563 | 0.77 | TLR4 (0.34) | TLR4TLR2 | |
| SCHEMBL6011959 | 0.73 | CYP3A4 (0.39) | — | |
| SCHEMBL9110384 | 0.73 | HDAC4 (0.42) | CHRM2CHRM1CHRM3NFE2L2 | |
| SCHEMBL9109996 | 0.73 | HDAC4 (0.42) | CHRM2CHRM1CHRM3NFE2L2 | |
| SCHEMBL12879696 | 0.69 | PNMT (0.38) | CHRM2CHRM1CHRM3 | |
| SCHEMBL2404950 | 0.69 | DRD2 (0.41) | CHRM2CHRM1CHRM3 | |
| SCHEMBL3389437 | 0.69 | ALDH1A1 (0.30) | — | |
| SCHEMBL3389431 | 0.69 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |