Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328794 | 0.93 | REN (0.48) | RENCTSDCTSSCTSKBACE1 | |
| SCHEMBL7325341 | 0.85 | CTSD (0.39) | RENCTSDBACE1 | |
| SCHEMBL7328982 | 0.85 | CTSD (0.41) | RENCTSD | |
| SCHEMBL7332297 | 0.85 | KLK5 (0.58) | RENCTSDKLK5CTSSCTSK | |
| SCHEMBL7323060 | 0.85 | REN (0.56) | RENCTSDKLK5BACE1 | |
| SCHEMBL7354721 | 0.85 | REN (0.56) | RENCTSDKLK5BACE1 | |
| SCHEMBL7322162 | 0.83 | CTSD (0.41) | RENCTSD | |
| SCHEMBL9754465 | 0.83 | CTSD (0.64) | RENCTSDKLK5PSEN1PSEN2 | |
| SCHEMBL7330753 | 0.82 | REN (0.49) | RENCTSDCTSSCTSKBACE1 | |
| SCHEMBL7332756 | 0.81 | REN (0.48) | RENCTSDCTSSCTSKBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990000399-A1 | RETROVIRAL PROTEASE BINDING PEPTIDES | SMITHKLINE BECKMAN CORPORATION (US) | 1990-01-25 | — | — | WO | disclosed |
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |