Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731737 | 0.86 | NR4A2 (0.40) | NR4A2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5502854 | 0.82 | DYRK1B (0.40) | DYRK1BNR4A2ALDH1A1MAPTHPGD | |
| SCHEMBL732379 | 0.82 | ALDH1A1 (0.47) | DYRK1BNR4A2ALDH1A1MAPTHPGD | |
| SCHEMBL16289769 | 0.80 | ALDH1A1 (0.38) | NR4A2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL24839312 | 0.79 | MEN1 (0.41) | DYRK1BNR4A2ALDH1A1MAPTHPGD | |
| SCHEMBL5050803 | 0.79 | SMN1; SMN2 (0.47) | NR4A2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL5054240 | 0.76 | TGFBR1 (0.43) | NR4A2ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL27590619 | 0.76 | DYRK1B (0.43) | DYRK1BNR4A2ALDH1A1MAPTHPGD | |
| SCHEMBL30051309 | 0.75 | NR4A2 (0.66) | DYRK1BNR4A2ALDH1A1MAPTHPGD | |
| SCHEMBL1888577 | 0.75 | NR4A2 (0.66) | DYRK1BNR4A2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-20230000869-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2023-01-05 | — | — | US | disclosed |
| US-11026947-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20200179389-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-06-11 | — | — | US | disclosed |
| EP-2998296-B1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2018-03-14 | — | — | EP | disclosed |
| EP-2998296-B1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2018-03-14 | — | — | EP | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | DARCY MICHAEL GERARD | 2008-10-16 | — | — | US | disclosed |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | DARCY MICHAEL GERARD | 2008-10-16 | — | — | US | disclosed |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | DARCY MICHAEL GERARD | 2008-10-16 | — | — | US | disclosed |
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2007136940-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007136940-A2 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007103756-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200179389-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | BMPR2, BMP1, BMP2K | DYRK1B 1054/4885NR4A2 2365/4885ALDH1A1 4733/4885 |
| US-20080255115-A1 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PI4KA, JAK3, PIK3CD | DYRK1B 2025/4885NR4A2 1126/4885ALDH1A1 636/4885 |
| US-20230000869-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | BMPR2, BMP1, BMP2K | DYRK1B 1054/4885NR4A2 2365/4885ALDH1A1 4733/4885 |
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | BMPR2, BMP1, BMP2K | DYRK1B 1257/4885NR4A2 1962/4885ALDH1A1 4711/4885 |
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | DYRK1B 1810/4885NR4A2 3824/4885ALDH1A1 4089/4885 |
| US-11026947-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | BMPR2, BMP1, BMP2K | DYRK1B 1257/4885NR4A2 1962/4885ALDH1A1 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.