SCHEMBL7324142

SCHEMBL7324142

CN(C)CCc1c[nH]c2ccc(-c3cccc4ccccc34)cc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 5/20 0.60
HTR2A P28223 4/20 0.60
HTR2C P28335 4/20 0.60
HTR2B P41595 3/20 0.60
HTR1D P28221 11/20 0.59
HTR1B P28222 9/20 0.59
HTR6 P50406 4/20 0.58
SLC6A4 P31645 2/20 0.55
MPO P05164 1/20 0.55
HTR3E A5X5Y0 2/20 0.53
HTR3B O95264 2/20 0.53
HTR1E P28566 2/20 0.53
HTR1F P30939 2/20 0.53
HTR7 P34969 2/20 0.53
HTR3A P46098 2/20 0.53
HTR5A P47898 2/20 0.53
HTR4 Q13639 2/20 0.53
HTR3D Q70Z44 2/20 0.53
HTR3C Q8WXA8 2/20 0.53
CYP1A2 P05177 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7391299 0.85 HTR6 (0.51) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL7325860 0.84 LTA4H (0.59) HTR1AHTR2AHTR2CHTR2BHTR1D
Hydrochloric Acid SCHEMBL7312565 0.82 LTA4H (0.61) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL7323553 0.82 HTR1D (0.68) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL8618818 0.80 HTR6 (0.51) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL7327470 0.79 HTR1D (0.62) HTR1AHTR2AHTR2CHTR2BHTR1D
SCHEMBL7325786 0.79 CSNK2A1 (0.55) HTR6SLC6A4MPO
N,N-Dimethyltryptamine SCHEMBL335710 0.77 HTR2A (1.00) HTR1AHTR2AHTR2CHTR2BHTR1D
N,N-Dimethyltryptamine SCHEMBL29350959 0.77 HTR2A (1.00) HTR1AHTR2AHTR2CHTR2BHTR1D
N,N-Dimethyltryptamine SCHEMBL27221709 0.77 HTR2A (1.00) HTR1AHTR2AHTR2CHTR2BHTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674620-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP disclosed
WO-1994014771-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO disclosed