Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 12/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46323 | 0.76 | GABRA5 (0.46) | GABRA5GABRG2GABRB3GABRA1CYP11B2 | |
| SCHEMBL7404024 | 0.76 | CYP11B2 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL21603212 | 0.75 | GABRA5 (0.46) | GABRA5GABRG2GABRB3GRM5GABRA1 | |
| SCHEMBL13178859 | 0.75 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL7318495 | 0.75 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL16972862 | 0.75 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL21603242 | 0.74 | GABRA5 (0.45) | GABRA5GABRG2GABRB3GRM5GABRA1 | |
| SCHEMBL10929292 | 0.73 | PDE3B (0.45) | GABRA5GABRA1TSHRHTT | |
| SCHEMBL7323714 | 0.72 | GABRA5 (0.41) | GABRA5GABRG2GABRB3GABRA1CYP11B2 | |
| SCHEMBL7328560 | 0.71 | GABRG2 (0.36) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357675-A4 | PYRIDOOXAZINONE-PYRIDONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | — | 1992-01-15 | — | — | EP | disclosed |
| WO-1991006300-A1 | NAPHTHERIDINONE- AND PYRIDOOXAZINONE-PYRIDONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING SAME, AND THEIR USES | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-05-16 | — | — | WO | disclosed |
| US-5015638-A | Cardiovascular disorders, cardiotonic agents for congestive he art failure | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0357675-A1 | PYRIDOOXAZINONE-PYRIDONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4866074-A | Naphtheridinone- and pyridooxazinone-pyridone compounds, cardiotonic compositions including same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4822794-A | Pyridooxazinone-pyridone compounds, cardiotonic compositions including the same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |
| WO-1988008705-A1 | PYRIDOOXAZINONE-PYRIDONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-11-17 | — | — | WO | disclosed |