Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 12/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46323 | 0.80 | GABRA5 (0.46) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL7318495 | 0.79 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL16972862 | 0.79 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL13178859 | 0.79 | GABRG2 (0.43) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL21603212 | 0.77 | GABRA5 (0.46) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL21603242 | 0.75 | GABRA5 (0.45) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL18227101 | 0.74 | TERT (0.44) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL9836345 | 0.73 | CYP11B2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL7324315 | 0.72 | GABRA5 (0.41) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 | |
| SCHEMBL19154094 | 0.72 | CYP11B2 (0.41) | GABRA5GABRG2GABRB3CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906629-A | Pyridazinone and pyrazolone compounds, cardiotonic compositions including same, and their uses | RORER PHARMACEUTICAL CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| US-4829066-A | CONGESTIVE HEART FAILURE | RORER PHARMACEUTICAL CORPORATION (US) | 1989-05-09 | — | — | US | disclosed |
| WO-1988008706-A1 | PYRIDOOXAZINONE-PYRIDAZINONE AND PYRAZOLONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-11-17 | — | — | WO | disclosed |