Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327714 | 0.95 | HCRTR1 (0.55) | HCRTR1KDM4EALDH1A1SMN1; SMN2POLB | |
| Oxalic Acid SCHEMBL7324624 | 0.85 | HCRTR1 (0.52) | HCRTR1KDM4EALDH1A1HCRTR2MEN1 | |
| Oxalic Acid SCHEMBL7321680 | 0.83 | FAAH (0.49) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL7359206 | 0.81 | LTA4H (0.55) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL7359209 | 0.81 | LTA4H (0.55) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL7330044 | 0.81 | MAOB (0.49) | SMN1; SMN2LMNAHRH3 | |
| SCHEMBL11447662 | 0.80 | LTA4H (0.53) | LTA4HHRH3 | |
| Oxalic Acid SCHEMBL9697739 | 0.79 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2POLBMEN1 | |
| SCHEMBL7329491 | 0.79 | MEN1 (0.50) | HCRTR1ALDH1A1HCRTR2MEN1KMT2A | |
| SCHEMBL7328727 | 0.78 | FAAH (0.51) | KDM4EALDH1A1MEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |