Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329491 | 0.94 | MEN1 (0.50) | HCRTR1HCRTR2HTTALDH1A1MAPT | |
| Oxalic Acid SCHEMBL7359209 | 0.86 | LTA4H (0.55) | KDM4EHTTALDH1A1S1PR4S1PR1 | |
| Oxalic Acid SCHEMBL7359206 | 0.86 | LTA4H (0.55) | KDM4EHTTALDH1A1S1PR4S1PR1 | |
| Oxalic Acid SCHEMBL7324613 | 0.85 | HCRTR1 (0.58) | HCRTR1HCRTR2KDM4EALDH1A1S1PR4 | |
| Oxalic Acid SCHEMBL7321680 | 0.82 | FAAH (0.49) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7330703 | 0.82 | HRH3 (0.52) | KDM4EALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL11447662 | 0.80 | LTA4H (0.53) | HRH3LTA4H | |
| Oxalic Acid SCHEMBL7330044 | 0.79 | MAOB (0.49) | HRH3LMNA | |
| SCHEMBL7327714 | 0.78 | HCRTR1 (0.55) | HCRTR1HCRTR2KDM4EALDH1A1S1PR4 | |
| Oxalic Acid SCHEMBL9699030 | 0.78 | KDM4E (0.56) | KDM4EHTTALDH1A1S1PR5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |