Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7359206 | 1.00 | LTA4H (0.55) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7330703 | 0.95 | HRH3 (0.52) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| Oxalic Acid SCHEMBL7324624 | 0.86 | HCRTR1 (0.52) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| Oxalic Acid SCHEMBL7324613 | 0.81 | HCRTR1 (0.58) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| Oxalic Acid SCHEMBL7320673 | 0.81 | KDM4E (0.61) | LTA4HKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7329491 | 0.80 | MEN1 (0.50) | LTA4HALDH1A1MEN1KMT2AHTT | |
| SCHEMBL14139379 | 0.80 | LTA4H (0.52) | LTA4HHRH3 | |
| Oxalic Acid SCHEMBL7330044 | 0.80 | MAOB (0.49) | HRH3SMN1; SMN2 | |
| Oxalic Acid SCHEMBL7321680 | 0.79 | FAAH (0.49) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL7322832 | 0.79 | SLC2A1 (0.59) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |