Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324689 | 0.83 | RAB9A (0.41) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL19266384 | 0.81 | GRM2 (0.50) | MAPTSMN1; SMN2GRM2CYP2C9CYP2C19 | |
| SCHEMBL16242750 | 0.78 | GRM2 (0.48) | MAPTSMN1; SMN2GRM2CYP2C9CYP2C19 | |
| SCHEMBL7390252 | 0.75 | ACHE (0.47) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL29639744 | 0.75 | MEN1 (0.58) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9720621 | 0.75 | HSP90AB1 (0.48) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL480863 | 0.75 | MEN1 (0.58) | MAPTMEN1NPC1RAB9AKMT2A | |
| SCHEMBL16242903 | 0.75 | MAPT (0.75) | MAPTSMN1; SMN2NPC1RAB9AGRM2 | |
| SCHEMBL9878237 | 0.75 | KDM4E (0.38) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL12723861 | 0.74 | ACHE (0.57) | RAB9ATDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703075-A | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0459983-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | PHARMACIA & UPJOHN COMPANY (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990006921-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1990-06-28 | — | — | WO | disclosed |