Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.42 |
| ▸ | XPO1 | O14980 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737451 | 1.00 | TRPA1 (0.43) | TRPA1NFE2L2XPO1ALDH1A1MEN1 | |
| SCHEMBL18706675 | 0.83 | LMNA (0.37) | XPO1ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL18706679 | 0.83 | LMNA (0.37) | XPO1ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL3310811 | 0.83 | NFE2L2 (0.47) | NFE2L2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL16642332 | 0.82 | ALDH1A1 (0.38) | XPO1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL15278593 | 0.82 | XPO1 (0.34) | XPO1ALDH1A1LMNAKMT2AMAPT | |
| SCHEMBL30288729 | 0.82 | ALDH1A1 (0.38) | XPO1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL19900075 | 0.82 | ALDH1A1 (0.38) | XPO1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL30288849 | 0.82 | XPO1 (0.37) | TRPA1XPO1LMNAKMT2ARAB9A | |
| SCHEMBL29385542 | 0.82 | ALDH1A1 (0.38) | XPO1ALDH1A1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426782-B | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER LTD | 2012-10-31 | — | — | CN | disclosed |
| US-8138188-B2 | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER INC. (US) | 2012-03-20 | — | — | US | disclosed |
| CN-101426782-A | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines | PFIZER LTD (GB) | 2009-05-06 | — | — | CN | disclosed |