Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ACE | P12821 | 2/20 | 0.67 |
| ▸ | ECE1 | P42892 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | ANPEP | P15144 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325845 | 1.00 | MME (1.00) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL7325857 | 1.00 | MME (1.00) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL10447979 | 0.86 | MME (0.81) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL10692379 | 0.82 | MME (0.70) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL10691553 | 0.82 | MME (0.70) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL825762 | 0.81 | MME (0.74) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL7103054 | 0.81 | MME (0.74) | MMEALDH1A1ACEECE1HPGD | |
| SCHEMBL9622302 | 0.80 | MME (0.72) | MMEALDH1A1ACEECE1HPGD | |
| Thiorphan SCHEMBL401174 | 0.80 | MME (1.00) | MMEALDH1A1ACEECE1HPGD | |
| (R)-Thiorphan SCHEMBL7312756 | 0.80 | MME (1.00) | MMEALDH1A1ACEECE1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-4749688-A | Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |