Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325363 | 0.89 | KDM4E (0.38) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL7323133 | 0.81 | ABCC9 (0.39) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL8076948 | 0.81 | ABCC9 (0.43) | KDM4EABCC9ABCB1 | |
| SCHEMBL8085380 | 0.80 | ABCC9 (0.43) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL7334787 | 0.80 | ABCC9 (0.55) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL7325866 | 0.77 | ABCB1 (0.39) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL7273801 | 0.77 | ABCC9 (0.39) | KDM4EABCC9ABCB1 | |
| SCHEMBL8085341 | 0.77 | ABCC9 (0.43) | KDM4EABCC9ABCB1 | |
| SCHEMBL8090511 | 0.69 | ABCC9 (0.40) | KDM4EABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL8088871 | 0.69 | ABCC9 (0.38) | KDM4EABCC9ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |