Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 10/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085312 | 0.89 | ABCC9 (0.40) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8090585 | 0.87 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8077260 | 0.85 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8084438 | 0.83 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8090464 | 0.82 | ABCB1 (0.39) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8090541 | 0.82 | AKR1B1 (0.32) | — | |
| SCHEMBL8085421 | 0.81 | HTR1A (0.32) | — | |
| SCHEMBL8088383 | 0.81 | ALDH1A1 (0.36) | ABCC9LMNA | |
| SCHEMBL8090733 | 0.80 | ABCB1 (0.40) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL8085200 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |