Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.66 |
| ▸ | CTSD | P07339 | 4/20 | 0.55 |
| ▸ | REN | P00797 | 5/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332668 | 0.93 | ACE (0.68) | ACECTSDRENKLK5CTSB | |
| SCHEMBL27292008 | 0.89 | ACE (0.58) | ACECTSDRENKLK5 | |
| SCHEMBL7697656 | 0.87 | CTSS (0.60) | ACECTSDRENKLK5CTSB | |
| SCHEMBL8141342 | 0.85 | CTSK (0.56) | CTSDKLK5CTSBCTSKCTSS | |
| SCHEMBL21684844 | 0.85 | CTSK (0.56) | CTSDKLK5CTSBCTSKCTSS | |
| SCHEMBL6279109 | 0.85 | CTSK (0.56) | CTSDKLK5CTSBCTSKCTSS | |
| SCHEMBL29770301 | 0.84 | CTSS (0.60) | CTSDRENKLK5CTSBCTSK | |
| SCHEMBL8137308 | 0.83 | MEN1 (0.55) | CTSDRENKLK5CTSBCTSK | |
| SCHEMBL30902823 | 0.82 | REN (0.55) | CTSDRENKLK5CTSBCTSK | |
| SCHEMBL7324257 | 0.81 | ACE (0.70) | ACERENKLK5CTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352000-A2 | Retroviral protease binding peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-24 | — | — | EP | disclosed |