SCHEMBL7326207

SCHEMBL7326207

CN(CCCc1ccc(C2CCCCC2)c(Cl)c1)CCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 13/20 0.48
TP53 P04637 3/20 0.44
CYP1A2 P05177 3/20 0.44
CYP2D6 P10635 2/20 0.44
TSHR P16473 2/20 0.44
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
CYP3A4 P08684 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44
SLC18A3 Q16572 2/20 0.43
SMPD1 P17405 1/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29412737 0.91 SIGMAR1 (0.47) SIGMAR1SLC18A3ALDH1A1MAPT
SCHEMBL7320066 0.91 SIGMAR1 (0.47) SIGMAR1SLC18A3ALDH1A1MAPT
SCHEMBL11632591 0.84 SIGMAR1 (0.43) SIGMAR1TP53CYP1A2CYP2D6TSHR
SCHEMBL11633835 0.79 SIGMAR1 (0.46) SIGMAR1CYP1A2CYP2D6TSHRCYP3A4
Hydrochloric Acid SCHEMBL30343200 0.78 SIGMAR1 (0.45) SIGMAR1CYP1A2CYP2D6TSHRCYP3A4
SCHEMBL8329233 0.78 SLC18A3 (0.36) SIGMAR1SLC18A3
SCHEMBL7322425 0.77 SLC6A4 (0.41) SIGMAR1SLC18A3
Hydrochloric Acid SCHEMBL7314216 0.77 OPRM1 (0.36) SIGMAR1SLC18A3
SCHEMBL7326682 0.76 SIGMAR1 (0.57) SIGMAR1CYP1A2CYP2D6TSHRCYP3A4
Hydrochloric Acid SCHEMBL9152015 0.75 SIGMAR1 (0.56) SIGMAR1CYP1A2CYP2D6TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235791-B1 USING CIS N-CYCLOHEXYL-N-ETHYL(3-(3-CHLORO-CYCLOHEXYLPHENYL)ALLYL)AMINE SANOFI-SYNTHELABO (FR) 2001-05-22 US disclosed
EP-0917464-A1 USE OF AMINES TO PRODUCE DRUGS FOR PREVENTING TUMOUR CELL PROLIFERATION SANOFI (FR) 1999-05-26 EP disclosed
WO-1998004251-A1 USE OF AMINES TO PRODUCE DRUGS FOR PREVENTING TUMOUR CELL PROLIFERATION SANOFI (FR) 1998-02-05 WO disclosed