Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312792 | 0.82 | AKR1C3 (0.50) | POLBTSHR | |
| SCHEMBL10662835 | 0.81 | CA12 (0.53) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL5925648 | 0.76 | NOTUM (0.51) | SIGMAR1HRH4HRH3POLBRXFP1 | |
| SCHEMBL6367385 | 0.73 | DAO (0.46) | SIGMAR1HRH4HRH3KDM4E | |
| SCHEMBL7317404 | 0.73 | CA12 (0.46) | SIGMAR1HRH4HRH3CA12BRD4 | |
| SCHEMBL6581393 | 0.72 | CA12 (0.52) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL30672091 | 0.71 | CA12 (0.55) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL6568800 | 0.71 | CA12 (0.55) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL6195893 | 0.69 | RAB9A (0.56) | CA12BRD4BRPF1CA9KAT2B | |
| SCHEMBL30804587 | 0.69 | RAB9A (0.56) | CA12BRD4BRPF1CA9KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | claimed |
| CN-1102527-A | Piperazinocarbonylcarbostyrils as peripheral vasodilators | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | CN | disclosed |
| CN-1102527-A | Piperazinocarbonylcarbostyrils as peripheral vasodilators | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | CN | disclosed |