SCHEMBL7326322

SCHEMBL7326322

COC(=O)c1ccc(C(=O)Cl)c2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.51
NR4A2 P43354 5/20 0.50
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.50
CREBBP Q92793 1/20 0.50
KDM4E B2RXH2 5/20 0.49
ALDH1A1 P00352 3/20 0.48
CFTR P13569 1/20 0.48
HSD17B10 Q99714 1/20 0.48
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.47
GAA P10253 1/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
HPGD P15428 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
PLK1 P53350 1/20 0.45
SLC6A4 P31645 1/20 0.45
SLC6A3 Q01959 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23909537 0.92 LMNA (0.50) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL29434198 0.90 BRD4 (0.59) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL70381 0.90 BRD4 (0.59) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL883106 0.85 BRD4 (0.49) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL29599305 0.83 ALDH1A1 (0.52) BRD4NR4A2TSHRKDM4EALDH1A1
SCHEMBL2154872 0.83 ALDH1A1 (0.52) BRD4NR4A2TSHRKDM4EALDH1A1
SCHEMBL5751153 0.83 KMT2A (0.59) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL5750893 0.82 BRD4 (0.53) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL31049722 0.82 BRD4 (0.53) BRD4NR4A2LMNATSHRCREBBP
SCHEMBL31049726 0.82 BRD4 (0.53) BRD4NR4A2LMNATSHRCREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103842365-A Cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists HOFFMANN LA ROCHE 2014-06-04 CN disclosed
CN-102884065-A Heteroaryl-cyclohexyl-tetraazabenzo [ e ] azulenes HOFFMANN LA ROCHE 2013-01-16 CN disclosed
CN-102858778-A Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes HOFFMANN LA ROCHE 2013-01-02 CN disclosed
US-6232290-B1 FUNGICIDES AGAINST PNEUMOCYSTIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-15 US disclosed
EP-1053247-A1 ANTIFUNGAL CYCLOHEXAPEPTIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-11-22 EP disclosed
WO-1999040108-A1 NEW COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-08-12 WO disclosed