Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.68 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329934 | 0.86 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL4014471 | 0.85 | ADORA2A (0.63) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8679545 | 0.82 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL27396492 | 0.81 | ADORA2A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL380135 | 0.81 | ADORA2A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7217322 | 0.80 | ADORA2A (0.97) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL985620 | 0.80 | ADORA2B (0.63) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL4602969 | 0.79 | ADORA2B (0.73) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL4423680 | 0.79 | ADORA2B (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL27586849 | 0.78 | ADORA2A (0.71) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485495-A1 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | Beecham Group p.l.c. (GB) | 1992-05-20 | — | — | EP | disclosed |
| WO-1991001730-A2 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | BEECHAM GROUP PLC (GB) | 1991-02-21 | — | — | WO | disclosed |
| EP-0260127-A2 | Xanthine derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-03-16 | — | — | EP | disclosed |