Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.57 |
| ▸ | PDE4A | P27815 | 4/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.57 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985624 | 0.80 | PNP (0.66) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL27936350 | 0.79 | ADORA2B (0.49) | ADORA2BADORA3ADORA2ADAOKDM4E | |
| SCHEMBL31060278 | 0.77 | ADORA2B (1.00) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL8750700 | 0.77 | ADORA2B (0.59) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL4014471 | 0.76 | ADORA2A (0.63) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL10818065 | 0.76 | ADORA2B (0.70) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL6267430 | 0.75 | PNP (0.45) | ADORA2BADORA3PDE4APDE4BPDE4C | |
| SCHEMBL4602969 | 0.74 | ADORA2B (0.73) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL380135 | 0.73 | ADORA2A (1.00) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL5515444 | 0.73 | ADORA2A (0.71) | ADORA2BADORA3ADORA2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005929-A1 | PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| US-20100144613-A1 | Combined use of DPP-IV Inhibitors and Gastrin Compounds | WARATAH PHARMACEUTICALS, INC. (CA) | 2010-06-10 | — | — | US | disclosed |
| US-20090054314-A1 | Combined use of DPP-IV inhibitors and gastrin compounds | WARATAH PHARMACEUTICALS INC. (CA) | 2009-02-26 | — | — | US | disclosed |
| WO-2004018467-A3 | PHENACYL XANTHINE DERIVATIVES AS DPP-IV INHIBITOR | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-05-13 | — | — | WO | disclosed |
| WO-2004018467-A2 | PHENACYL XANTHINE DERIVATIVES AS DPP-IV INHIBITOR | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | disclosed |