Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.57 |
| ▸ | HTR1B | P28222 | 5/20 | 0.57 |
| ▸ | HTR1A | P08908 | 7/20 | 0.55 |
| ▸ | HTR2A | P28223 | 7/20 | 0.55 |
| ▸ | HTR2C | P28335 | 5/20 | 0.55 |
| ▸ | MPO | P05164 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 1/20 | 0.55 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331855 | 0.83 | HTR1D (0.60) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL2536567 | 0.81 | LTA4H (0.67) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL7359803 | 0.80 | CSNK2A1 (0.55) | MPOCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8475787 | 0.78 | HTR1D (0.54) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL31370163 | 0.77 | KMT2A (0.62) | HTR1AHTR2AHTR2CMPOCYP3A4 | |
| Hydrochloric Acid SCHEMBL7313598 | 0.77 | LTA4H (0.65) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9238831 | 0.76 | HTR6 (0.58) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL7334745 | 0.75 | HTR1D (0.64) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8869386 | 0.75 | TRPM8 (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL7325860 | 0.75 | LTA4H (0.59) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |