Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.58 |
| ▸ | PDE4A | P27815 | 4/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.58 |
| ▸ | XDH | P47989 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326505 | 1.00 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4CXDH | |
| SCHEMBL7327071 | 0.95 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CXDH | |
| SCHEMBL7326140 | 0.95 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4CXDH | |
| SCHEMBL7560477 | 0.85 | ALDH1A1 (0.64) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL29808190 | 0.85 | ALDH1A1 (0.64) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL70835 | 0.85 | ALDH1A1 (0.64) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL4637156 | 0.84 | ALDH1A1 (0.62) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL6883557 | 0.84 | ALDH1A1 (0.66) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL7733862 | 0.83 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL7325691 | 0.82 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |