Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322432 | 0.89 | LMNA (0.41) | DHPSEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7332509 | 0.87 | RORC (0.38) | MEN1KMT2APOLBHPGDALDH1A1 | |
| SCHEMBL7292782 | 0.87 | EDNRA (0.40) | DHPSEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7302917 | 0.85 | EDNRA (0.51) | DHPSEDNRA | |
| SCHEMBL7296309 | 0.84 | EDNRA (0.39) | DHPSEDNRA | |
| SCHEMBL7303989 | 0.84 | DHPS (0.47) | DHPSEDNRAHTTPOLBMCL1 | |
| SCHEMBL7333240 | 0.84 | EDNRA (0.50) | DHPSEDNRA | |
| SCHEMBL7293765 | 0.83 | EDNRA (0.44) | DHPSEDNRAMEN1KMT2ALMNA | |
| SCHEMBL7297143 | 0.82 | DHPS (0.42) | DHPSEDNRAMCL1RORC | |
| SCHEMBL7302684 | 0.82 | DHPS (0.38) | DHPSEDNRALMNARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |