Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.51 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 11/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | EED | O75530 | 2/20 | 0.42 |
| ▸ | DCAF15 | Q66K64 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336717 | 0.90 | HDAC8 (0.51) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL86872 | 0.81 | DNMT1 (0.53) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL7335039 | 0.81 | HDAC8 (0.56) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| Bromide SCHEMBL82425 | 0.80 | DNMT1 (0.51) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL7326253 | 0.80 | DNMT1 (0.51) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL7330633 | 0.78 | HDAC8 (0.53) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL31167506 | 0.78 | HDAC8 (0.57) | SMARCA2PTAFRHDAC8HDAC4HDAC5 | |
| SCHEMBL7335787 | 0.78 | HDAC8 (0.56) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL7332041 | 0.75 | HDAC8 (0.53) | DNMT1RAD52UHRF1SMARCA2PTAFR | |
| SCHEMBL7338632 | 0.75 | HDAC8 (0.53) | DNMT1RAD52UHRF1SMARCA2PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| EP-0491814-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | NOVO NORDISK AS (DK) | 1992-07-01 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| WO-1991003478-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |