Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.39 |
| ▸ | PTAFR | P25105 | 2/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335787 | 0.85 | HDAC8 (0.56) | HDAC8HDAC4HDAC5PTAFRHDAC3 | |
| SCHEMBL7338632 | 0.82 | HDAC8 (0.53) | HDAC8HDAC4HDAC5PTAFRHDAC3 | |
| SCHEMBL7328322 | 0.82 | HDAC8 (0.41) | HDAC8HDAC4HDAC5PTAFRHDAC3 | |
| SCHEMBL7335813 | 0.79 | SLC6A2 (0.46) | HDAC8HDAC4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7326935 | 0.75 | DNMT1 (0.51) | HDAC8HDAC4HDAC5PTAFREED | |
| SCHEMBL31050084 | 0.73 | HDAC8 (0.41) | HDAC8HDAC4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7330633 | 0.71 | HDAC8 (0.53) | HDAC8HDAC4HDAC5PTAFREED | |
| SCHEMBL31746720 | 0.68 | DNMT1 (0.43) | HDAC8HDAC4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7336717 | 0.67 | HDAC8 (0.51) | HDAC8HDAC4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31167506 | 0.65 | HDAC8 (0.57) | HDAC8HDAC4HDAC5PTAFRHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| EP-0491814-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | NOVO NORDISK AS (DK) | 1992-07-01 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| WO-1991003478-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |