Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 4/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326935 | 0.78 | DNMT1 (0.51) | HDAC8HDAC4PTAFRSMARCA2HDAC5 | |
| SCHEMBL31167506 | 0.73 | HDAC8 (0.57) | HDAC8HDAC4HDAC6PTAFRSMARCA2 | |
| SCHEMBL7332041 | 0.71 | HDAC8 (0.53) | HDAC8HDAC4HDAC6PTAFRSMARCA2 | |
| SCHEMBL7336717 | 0.70 | HDAC8 (0.51) | HDAC8HDAC4HDAC6PTAFRSMARCA2 | |
| SCHEMBL12533812 | 0.69 | KMT2A (0.44) | HDAC8 | |
| SCHEMBL10822759 | 0.68 | HDAC8 (0.50) | HDAC8PTAFR | |
| SCHEMBL7335787 | 0.67 | HDAC8 (0.56) | HDAC8HDAC4HDAC6PTAFRSMARCA2 | |
| SCHEMBL18824723 | 0.67 | HDAC8 (0.71) | HDAC8HDAC4HDAC6HDAC5 | |
| SCHEMBL7328322 | 0.65 | HDAC8 (0.41) | HDAC8HDAC4HDAC6PTAFRSMARCA2 | |
| SCHEMBL7335813 | 0.65 | SLC6A2 (0.46) | HDAC8HDAC4HDAC6PTAFRHDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| EP-0491814-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | NOVO NORDISK AS (DK) | 1992-07-01 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| WO-1991003478-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |