Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325384 | 0.79 | TSHR (0.50) | LMNAL3MBTL1CES1KMT2AMAPT | |
| SCHEMBL24157492 | 0.79 | TSHR (0.50) | LMNAL3MBTL1CES1KMT2AMAPT | |
| SCHEMBL7327051 | 0.77 | LMNA (0.45) | LMNANAPRTP4HTML3MBTL1GPR52 | |
| SCHEMBL1915970 | 0.76 | CPA3 (0.56) | PKMCYP1A2 | |
| SCHEMBL24862890 | 0.73 | CAPN1 (0.56) | KMT2AMAPTSMN1; SMN2KDM4EHTT | |
| SCHEMBL1515752 | 0.73 | LMNA (0.59) | LMNANAPRTP4HTML3MBTL1GPR52 | |
| SCHEMBL24157470 | 0.72 | MAPT (0.55) | L3MBTL1CES2CES1KMT2AMAPT | |
| SCHEMBL24157467 | 0.72 | MAPT (0.55) | L3MBTL1CES2CES1KMT2AMAPT | |
| SCHEMBL4036991 | 0.72 | PTPRA (0.56) | LMNANAPRTP4HTML3MBTL1CTNNB1 | |
| SCHEMBL7266299 | 0.72 | EPHX1 (0.54) | KMT2APKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292800-A2 | Amino acid derivatives | MERCK PATENT GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |
| EP-0249096-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1987-12-16 | — | — | EP | disclosed |