Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27310886 | 0.96 | MTNR1A (0.43) | MTNR1AKDM4EALDH1A1GAAGPR84 | |
| SCHEMBL2313397 | 0.95 | MTNR1A (0.41) | MTNR1AKDM4EALDH1A1GAAGPR84 | |
| SCHEMBL2309760 | 0.93 | MTNR1A (0.40) | MTNR1AKDM4EALDH1A1GAAGPR84 | |
| SCHEMBL1456304 | 0.89 | ALDH1A1 (0.43) | MTNR1AKDM4EALDH1A1GAAMAPT | |
| SCHEMBL6276959 | 0.89 | MTNR1A (0.38) | MTNR1AKDM4EALDH1A1GAAGPR84 | |
| SCHEMBL2306866 | 0.87 | KDM4E (0.42) | MTNR1AKDM4EALDH1A1GAAMAPT | |
| SCHEMBL9858830 | 0.84 | ALDH1A1 (0.44) | MTNR1AKDM4EALDH1A1GAAMAPT | |
| SCHEMBL15921658 | 0.84 | ALDH1A1 (0.42) | MTNR1AKDM4EALDH1A1GAAMAPT | |
| SCHEMBL31131331 | 0.82 | MTNR1A (0.50) | MTNR1AKDM4EALDH1A1GAAGPR84 | |
| SCHEMBL80656 | 0.82 | MTNR1A (0.50) | MTNR1AKDM4EALDH1A1GAAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119529-B1 | CHEMICAL CONSTRUCTS | GLAXO GROUP LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| EP-1218319-A1 | CHEMICAL CONSTRUCTS | GLAXO GROUP LIMITED (GB) | 2002-07-03 | — | — | EP | disclosed |
| EP-1119529-A2 | CHEMICAL CONSTRUCTS | GLAXO GROUP LIMITED (GB) | 2001-08-01 | — | — | EP | disclosed |
| WO-2001025171-A1 | CHEMICAL CONSTRUCTS | GLAXO GROUP LIMITED (GB) | 2001-04-12 | — | — | WO | disclosed |
| WO-2000020357-A2 | CHEMICAL CONSTRUCTS | GLAXO GROUP LIMITED (GB) | 2000-04-13 | — | — | WO | disclosed |