Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327570 | 0.91 | MAPT (0.46) | MAPTMEN1KMT2ACYP1A2POLB | |
| SCHEMBL7325548 | 0.85 | SMN1; SMN2 (0.45) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL7327986 | 0.83 | L3MBTL1 (0.47) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7324842 | 0.81 | KDM4E (0.43) | ALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL7326394 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2ACYP1A2ALDH1A1HPGD | |
| SCHEMBL7328287 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2ACYP1A2ALDH1A1HPGD | |
| SCHEMBL7326401 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2ACYP1A2ALDH1A1HPGD | |
| SCHEMBL6851321 | 0.80 | HPGD (0.48) | MAPTMEN1KMT2APOLBHPGD | |
| Hydrochloric Acid SCHEMBL7324768 | 0.80 | SMN1; SMN2 (0.54) | MEN1KMT2ACYP1A2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7326067 | 0.80 | SMN1; SMN2 (0.54) | MEN1KMT2ACYP1A2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |