Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327993 | 0.91 | HTR3A (0.50) | L3MBTL1KDM4ETP53LIMK2GAA | |
| SCHEMBL7324842 | 0.86 | KDM4E (0.43) | L3MBTL1KDM4EALDH1A1TDP1LMNA | |
| SCHEMBL7325548 | 0.86 | SMN1; SMN2 (0.45) | L3MBTL1TP53GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL7328287 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7326401 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7326394 | 0.85 | SMN1; SMN2 (0.55) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL7331894 | 0.84 | SMN1; SMN2 (0.54) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL7324768 | 0.84 | SMN1; SMN2 (0.54) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL7326067 | 0.84 | SMN1; SMN2 (0.54) | L3MBTL1KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7327002 | 0.84 | SMN1; SMN2 (0.53) | GAAALDH1A1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |