Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324856 | 0.91 | HTR3A (0.51) | KDM4ELMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL7327986 | 0.86 | L3MBTL1 (0.47) | KDM4ELMNAALDH1A1HTR3AADRA2A | |
| Fumaric Acid SCHEMBL7324504 | 0.86 | HTR3A (0.46) | KDM4ELMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL7325548 | 0.84 | SMN1; SMN2 (0.45) | LMNAALDH1A1RXFP1L3MBTL1 | |
| Fumaric Acid SCHEMBL7323992 | 0.84 | KDM4E (0.51) | KDM4ELMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL7326394 | 0.83 | SMN1; SMN2 (0.55) | KDM4ELMNAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7328287 | 0.83 | SMN1; SMN2 (0.55) | KDM4ELMNAALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7326401 | 0.83 | SMN1; SMN2 (0.55) | KDM4ELMNAALDH1A1HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7324768 | 0.83 | SMN1; SMN2 (0.54) | KDM4ELMNAALDH1A1HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7331894 | 0.83 | SMN1; SMN2 (0.54) | KDM4ELMNAALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |