Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325553 | 0.91 | HTR3A (0.47) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7327986 | 0.86 | L3MBTL1 (0.47) | SMN1; SMN2KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7327561 | 0.85 | MAPT (0.46) | KMT2AMEN1ALDH1A1L3MBTL1POLB | |
| SCHEMBL7324842 | 0.84 | KDM4E (0.43) | ALDH1A1L3MBTL1LMNARXFP1 | |
| SCHEMBL7326394 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7326401 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7328287 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL6851321 | 0.83 | HPGD (0.48) | SMN1; SMN2KMT2AMEN1LMNADDB1 | |
| Hydrochloric Acid SCHEMBL7324768 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7331894 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2TSHRKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |