SCHEMBL7327630

SCHEMBL7327630

COC(=O)CNC(=O)COc1ccc(C(C)=O)cc1

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.51
GAA P10253 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
MAPT P10636 4/20 0.49
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 1/20 0.48
LMNA P02545 3/20 0.48
POLB P06746 3/20 0.47
NPSR1 Q6W5P4 1/20 0.47
PKM P14618 1/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8603654 0.87 NPC1 (0.55) L3MBTL1GAASMN1; SMN2ALDH1A1POLB
SCHEMBL7327922 0.84 GSK3B (0.54) L3MBTL1SMN1; SMN2MAPTALDH1A1LMNA
SCHEMBL6960461 0.84 L3MBTL1 (0.61) L3MBTL1GAAMAPTALDH1A1LMNA
SCHEMBL11162047 0.83 KMT2A (0.61) SMN1; SMN2KDM4EPOLBPKMMEN1
SCHEMBL14821487 0.78 LMNA (0.46) SMN1; SMN2MAPTALDH1A1KDM4ELMNA
SCHEMBL14821470 0.78 LMNA (0.46) SMN1; SMN2MAPTALDH1A1KDM4ELMNA
SCHEMBL8407405 0.77 MAPT (0.65) GAASMN1; SMN2MAPTALDH1A1KDM4E
Formamide SCHEMBL11664406 0.77 L3MBTL1 (0.53) L3MBTL1GAAMAPTALDH1A1LMNA
SCHEMBL459533 0.77 L3MBTL1 (0.66) L3MBTL1GAASMN1; SMN2MAPTALDH1A1
SCHEMBL24648938 0.77 SMN1; SMN2 (0.74) L3MBTL1GAASMN1; SMN2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0691959-B1 HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS ZENECA LTD (GB) 1998-07-22 EP disclosed
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US disclosed
US-5652242-A 3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BURYIC ACID, AMIDE OR ESTER; INHIBITORS OF BINDING OF FIBRINOGEN TO GLYCOPROTEIN ZENECA LIMITED (GB) 1997-07-29 US disclosed
US-5563141-A INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION ZENECA LIMITED (GB) 1996-10-08 US disclosed
US-5556977-A ANTIAGGLOMERANTS FOR CELLS, ANTICOAGULANTS, ANTIISCHEMIC AGENTS USING PYRIDINYLPIPERAZINE DERIVATIVES ZENECA LIMITED (GB) 1996-09-17 US disclosed
EP-0691959-A1 HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-17 EP disclosed
EP-0690847-A1 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-10 EP disclosed
WO-1994022835-A2 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 WO disclosed
WO-1994022834-A1 HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 WO disclosed