Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.37 |
| ▸ | EDNRB | P24530 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331086 | 0.89 | EDNRA (0.36) | EDNRAEDNRBRORCMCL1POLB | |
| SCHEMBL7332509 | 0.85 | RORC (0.38) | RORCMCL1BCL2L1POLBMEN1 | |
| SCHEMBL8327618 | 0.84 | EDNRA (0.42) | EDNRAEDNRBMCL1BCL2L1POLB | |
| SCHEMBL7322839 | 0.81 | EDNRA (0.42) | EDNRAEDNRBMCL1POLBMEN1 | |
| SCHEMBL8325946 | 0.78 | MAPT (0.38) | RORCMCL1BCL2L1POLBMEN1 | |
| SCHEMBL8321015 | 0.78 | EDNRA (0.45) | EDNRAEDNRBMCL1KEAP1NFE2L2 | |
| SCHEMBL8326182 | 0.78 | EDNRB (0.45) | EDNRAEDNRBRORCMCL1BCL2L1 | |
| SCHEMBL7293953 | 0.78 | MCL1 (0.40) | RORCMCL1BCL2L1POLBMEN1 | |
| SCHEMBL7333240 | 0.78 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7011111 | 0.76 | EDNRB (0.39) | EDNRAEDNRBRORCMCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | claimed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | claimed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |