Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332509 | 0.92 | RORC (0.38) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL7293953 | 0.90 | MCL1 (0.40) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL8327618 | 0.88 | EDNRA (0.42) | MAPTPOLBNR1H2MCL1BCL2L1 | |
| SCHEMBL7331086 | 0.81 | EDNRA (0.36) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL7326214 | 0.80 | NR1H2 (0.40) | MAPTRORCNR1H2MCL1BCL2L1 | |
| SCHEMBL7009283 | 0.80 | EDNRB (0.40) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL7326664 | 0.79 | DHPS (0.42) | POLBRORCMCL1BCL2L1KMT2A | |
| SCHEMBL7011111 | 0.79 | EDNRB (0.39) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL7007654 | 0.79 | MCL1 (0.40) | MAPTPOLBRORCNR1H2MCL1 | |
| SCHEMBL7327693 | 0.78 | EDNRA (0.37) | POLBRORCNR1H2MCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |