Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CPA1 | P15085 | 7/20 | 0.56 |
| ▸ | CPA3 | P15088 | 3/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.56 |
| ▸ | CPB1 | P15086 | 1/20 | 0.56 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909236 | 1.00 | CYP1A2 (0.63) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7349315 | 1.00 | CYP1A2 (0.63) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7076041 | 0.88 | MMP2 (0.72) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL17697191 | 0.87 | MMP2 (0.54) | CYP1A2MMP1MMP2MMP3MMP9 | |
| SCHEMBL7369644 | 0.87 | CYP1A2 (0.50) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7080740 | 0.85 | MMP1 (0.55) | CYP1A2MMP1MMP2MMP3MMP9 | |
| SCHEMBL7870903 | 0.82 | MMP2 (0.51) | CYP1A2MMP1MMP2MMP3MMP9 | |
| SCHEMBL7332196 | 0.81 | CYP1A2 (0.61) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7326144 | 0.81 | CYP1A2 (0.61) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7332201 | 0.81 | CYP1A2 (0.61) | CYP1A2CPA1CPA3FOLH1CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461074-A | Dipropargyl containing aryl/alkyl sulfur/or sulfonyl/or sulfoxide terminated aminodiol compounds are used as renin inhibitor; therpeutical | G.D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| US-5268391-A | Cardiovascular disorders | C. D. SEARLE & CO. (US) | 1993-12-07 | — | — | US | disclosed |
| US-5246969-A | Oligopeptides as renin inhibitors | G. D. SEARLE & CO. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5204357-A | RENIN-INHIBITING AMINO ACID DERIVATIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-20 | — | — | US | disclosed |
| US-4914129-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1990-04-03 | — | — | US | disclosed |
| US-4889869-A | ANTIALDOSTERONISM AGENTS | CIBA-GEIGY CORPORATION (US) | 1989-12-26 | — | — | US | disclosed |
| US-4758584-A | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups | CIBA-GEIGY CORPORATION (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0236734-A2 | 5-Amino-4-hydroxyvaleryl derivatives substituted by s-containing groups | CIBA-GEIGY AG (CH) | 1987-09-16 | — | — | EP | disclosed |