SCHEMBL8909236

SCHEMBL8909236

O=C(O)[C@H](Cc1ccccc1)CS(=O)(=O)c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.63
CPA1 P15085 7/20 0.56
CPA3 P15088 3/20 0.56
FOLH1 Q04609 3/20 0.56
CPB1 P15086 1/20 0.56
CPB2 Q96IY4 1/20 0.56
MMP1 P03956 1/20 0.55
MMP2 P08253 1/20 0.55
MMP3 P08254 1/20 0.55
MMP9 P14780 1/20 0.55
MMP8 P22894 1/20 0.55
SLC1A3 P43003 1/20 0.51
SLC1A2 P43004 1/20 0.51
SLC1A1 P43005 1/20 0.51
MME P08473 1/20 0.49
NAALAD2 Q9Y3Q0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7327841 1.00 CYP1A2 (0.63) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL7349315 1.00 CYP1A2 (0.63) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL7076041 0.88 MMP2 (0.72) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL17697191 0.87 MMP2 (0.54) CYP1A2MMP1MMP2MMP3MMP9
SCHEMBL7369644 0.87 CYP1A2 (0.50) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL7080740 0.85 MMP1 (0.55) CYP1A2MMP1MMP2MMP3MMP9
SCHEMBL7870903 0.82 MMP2 (0.51) CYP1A2MMP1MMP2MMP3MMP9
SCHEMBL7332201 0.81 CYP1A2 (0.61) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL7326144 0.81 CYP1A2 (0.61) CYP1A2CPA1CPA3FOLH1CPB1
SCHEMBL7332196 0.81 CYP1A2 (0.61) CYP1A2CPA1CPA3FOLH1CPB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688946-A DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS HOFFMANN LA ROCHE INC. (US) 1997-11-18 US disclosed
US-5204357-A RENIN-INHIBITING AMINO ACID DERIVATIVES HOECHST AKTIENGESELLSCHAFT (DE) 1993-04-20 US disclosed