Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332041 | 0.82 | HDAC8 (0.53) | HDAC8HDAC4HDAC5HDAC3HDAC1 | |
| SCHEMBL7338632 | 0.82 | HDAC8 (0.53) | HDAC8HDAC4PTGS2HDAC5HDAC3 | |
| SCHEMBL7335787 | 0.81 | HDAC8 (0.56) | HDAC8HDAC4HDAC5HDAC3HDAC1 | |
| SCHEMBL7335813 | 0.76 | SLC6A2 (0.46) | HDAC8HDAC4PTGS2HDAC5HDAC3 | |
| SCHEMBL7326935 | 0.72 | DNMT1 (0.51) | HDAC8HDAC4HDAC5PTAFRSMARCA2 | |
| SCHEMBL28378606 | 0.66 | PTAFR (0.42) | HDAC8HDAC4PTGS2HDAC5PTAFR | |
| SCHEMBL7330633 | 0.65 | HDAC8 (0.53) | HDAC8HDAC4HDAC5HDAC6PTAFR | |
| SCHEMBL7336717 | 0.64 | HDAC8 (0.51) | HDAC8HDAC4HDAC5HDAC3HDAC1 | |
| SCHEMBL31050084 | 0.62 | HDAC8 (0.41) | HDAC8HDAC4PTGS2HDAC5PTAFR | |
| SCHEMBL31167506 | 0.62 | HDAC8 (0.57) | HDAC8HDAC4HDAC5HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0491814-B1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK AS (DK) | 1995-12-06 | — | — | EP | disclosed |
| EP-0491814-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS. | NOVO NORDISK AS (DK) | 1992-07-01 | — | — | EP | disclosed |
| US-5100895-A | Imidazoquinazoline compounds; anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, improving cognitive function | NOVO NORDISK A/S (DK) | 1992-03-31 | — | — | US | disclosed |
| WO-1991003478-A1 | TETRACYCLIC IMIDAZOQUINAZOLINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NOVO NORDISK A/S (DK) | 1991-03-21 | — | — | WO | disclosed |
| EP-0417027-A1 | Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | NOVO NORDISK A/S (DK) | 1991-03-13 | — | — | EP | disclosed |