Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327732 | 0.85 | TNKS (0.39) | TNKSKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7327605 | 0.84 | TNKS (0.53) | TNKSKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7331035 | 0.82 | MAPT (0.48) | ALDH1A1MAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7329545 | 0.77 | TNKS (0.41) | TNKSKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7336871 | 0.75 | MAP2K1 (0.44) | TNKSKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7337601 | 0.74 | TNKS (0.43) | TNKSPARP1TNKS2ADORA3 | |
| SCHEMBL7328423 | 0.73 | MAPT (0.42) | TNKSKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL7339375 | 0.73 | TNKS (0.71) | TNKSMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL7328372 | 0.72 | NPC1 (0.35) | KDM4EALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7337908 | 0.72 | SCN10A (0.38) | TNKSKDM4EALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |