Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.43 |
| ▸ | PARP1 | P09874 | 10/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.36 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.36 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337908 | 0.84 | SCN10A (0.38) | TNKSTNKS2PARP1WNT3A | |
| SCHEMBL7397534 | 0.84 | TNKS (0.41) | TNKSTNKS2PARP1ADORA3SLC6A3 | |
| SCHEMBL7327605 | 0.84 | TNKS (0.53) | TNKSTNKS2PARP1ADORA3SLC6A3 | |
| SCHEMBL7329545 | 0.83 | TNKS (0.41) | TNKSTNKS2PARP1 | |
| SCHEMBL7327732 | 0.82 | TNKS (0.39) | TNKSTNKS2PARP1ADORA3 | |
| SCHEMBL7336871 | 0.81 | MAP2K1 (0.44) | TNKSTNKS2PARP1ADORA3 | |
| SCHEMBL7328423 | 0.79 | MAPT (0.42) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL7328378 | 0.74 | TNKS (0.38) | TNKSTNKS2PARP1ADORA3 | |
| SCHEMBL7330451 | 0.73 | BRD4 (0.41) | TNKSTNKS2PARP1 | |
| SCHEMBL15287390 | 0.73 | TNKS (0.71) | TNKSTNKS2PARP1ADORA3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |