Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330447 | 0.86 | BRD4 (0.41) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7327728 | 0.85 | TNKS (0.37) | ALDH1A1KDM4EMAPTADORA3 | |
| SCHEMBL7327598 | 0.84 | TNKS (0.41) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL7331031 | 0.82 | MAPT (0.48) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7329537 | 0.77 | ALDH1A1 (0.37) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL7331334 | 0.76 | BRD4 (0.36) | NPC1RAB9ATDP2ALDH1A1KDM4E | |
| SCHEMBL7337599 | 0.74 | TNKS (0.39) | TDP2ALDH1A1KDM4E | |
| SCHEMBL7338197 | 0.73 | CTSV (0.35) | MEN1KMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7328378 | 0.72 | TNKS (0.38) | NPC1RAB9ATDP2MEN1CASP3 | |
| SCHEMBL17016650 | 0.67 | PARP1 (0.45) | NPC1RAB9AL3MBTL1XDHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726900-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012594-A1 | 7H-IMIDAZO(1,2-a)PYRAZINE-8-ONE NMDA RECEPTOR ANTAGONISTS | RHONE-POULENC RORER S.A. (FR) | 1995-05-11 | — | — | WO | disclosed |