Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1469483 | 0.79 | LMNA (0.68) | LMNAPOLBALDH1A1NPSR1KMT2A | |
| SCHEMBL13195396 | 0.77 | LMNA (0.37) | LMNAMGLL | |
| SCHEMBL1796877 | 0.77 | LMNA (0.40) | LMNAMGLLKMT2AMEN1 | |
| SCHEMBL1799985 | 0.77 | MGLL (0.34) | LMNAMGLL | |
| SCHEMBL2411964 | 0.76 | LMNA (0.42) | LMNAALDH1A1MGLLKMT2AMEN1 | |
| SCHEMBL4680523 | 0.75 | L3MBTL1 (0.33) | MAPK1 | |
| SCHEMBL6887194 | 0.75 | MGLL (0.34) | POLBALDH1A1MGLLKMT2AMEN1 | |
| SCHEMBL1470146 | 0.74 | LMNA (0.61) | LMNAPOLBALDH1A1MGLL | |
| SCHEMBL18748771 | 0.74 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL1469108 | 0.73 | LMNA (0.60) | LMNAPOLBALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434365-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1991-06-26 | — | — | EP | disclosed |