Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 8/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001207 | 0.87 | MAPK13 (0.54) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL7337187 | 0.87 | GABRA2 (0.58) | GABRA2GABRA1GABRA3GABRA5PARP1 | |
| SCHEMBL7338092 | 0.87 | GABRA2 (0.60) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL8103362 | 0.86 | GABRA2 (0.65) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL7335981 | 0.81 | GABRA3 (0.64) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL9831660 | 0.79 | PARP1 (0.42) | PARP1 | |
| SCHEMBL7329523 | 0.77 | GABRA1 (0.60) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL7328729 | 0.77 | GABRA1 (1.00) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL7329155 | 0.76 | GABRA3 (0.49) | GABRA2GABRA1GABRA3GABRA5 | |
| SCHEMBL7330178 | 0.76 | GABRA1 (0.75) | GABRA2GABRA1GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | claimed |
| US-5095015-A | G-aminobutyric acid, anticonvulsants, tranquilizers, sleep disorders | NEUROGEN CORPORATION (US) | 1992-03-10 | — | — | US | claimed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | claimed |
| US-5510480-A | FOR SELECTIVE BINDING WITH GAMMA-AMINOBUTYRIC ACID RECEPTORS | NEUROGEN CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |
| US-5328912-A | Psychological disorders, cognition activators | NEUROGEN CORPORATION (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |