Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337187 | 0.85 | GABRA2 (0.58) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL8097270 | 0.85 | GABRA1 (0.63) | GABRA1GABRA2GABRA3GABRA5NPC1 | |
| SCHEMBL7338092 | 0.85 | GABRA2 (0.60) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL9001299 | 0.82 | GABRA1 (0.70) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7328607 | 0.77 | GABRA2 (0.62) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL9001207 | 0.77 | MAPK13 (0.54) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7333328 | 0.76 | GABRA1 (1.00) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7334605 | 0.75 | GABRA1 (0.76) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7335981 | 0.75 | GABRA3 (0.64) | GABRA1GABRA2GABRA3GABRA5 | |
| SCHEMBL7329155 | 0.75 | GABRA3 (0.49) | GABRA1GABRA2GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | claimed |
| US-5095015-A | G-aminobutyric acid, anticonvulsants, tranquilizers, sleep disorders | NEUROGEN CORPORATION (US) | 1992-03-10 | — | — | US | claimed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | claimed |
| US-5510480-A | FOR SELECTIVE BINDING WITH GAMMA-AMINOBUTYRIC ACID RECEPTORS | NEUROGEN CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |
| US-5328912-A | Psychological disorders, cognition activators | NEUROGEN CORPORATION (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0536295-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000296-A1 | CERTAIN AZACYCLOALKYL IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |