Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | TLR2 | O60603 | 2/20 | 0.51 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328818 | 1.00 | SIRT2 (0.53) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL5275326 | 0.86 | SIRT2 (0.54) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL10100518 | 0.83 | CTSL (0.58) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL27110953 | 0.83 | CTSL (0.55) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL5492475 | 0.83 | SIRT2 (0.52) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL5268864 | 0.82 | SIRT2 (0.55) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL19519898 | 0.82 | CTSL (0.59) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL7320613 | 0.81 | TRPM8 (0.58) | CTSLCTSS | |
| SCHEMBL5889247 | 0.81 | TRPM8 (0.58) | CTSLCTSS | |
| SCHEMBL5973119 | 0.81 | CTSL (0.58) | SIRT2SIRT1SIRT3CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558603-B1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO CO (US) | 1998-08-26 | — | — | EP | disclosed |
| US-5698569-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5622949-A | AIDS THERAPY | G. D. SEARLE & CO. (US) | 1997-04-22 | — | — | US | disclosed |
| US-5620977-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0558673-B1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO CO (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5475013-A | Inhibit human immunodeficiency virus protease | MONSANTO COMPANY (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0558603-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1993-09-08 | — | — | EP | disclosed |
| EP-0558673-A1 | RETROVIRAL PROTEASE INHIBITORS. | MONSANTO CO (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992008688-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |
| WO-1992008699-A1 | RETROVIRAL PROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |