Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.59 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319750 | 0.93 | PRSS1 (0.66) | PRSS1TMPRSS15ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7328928 | 0.85 | PRSS1 (0.55) | PRSS1TMPRSS15VCAM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7320813 | 0.84 | PRSS1 (0.53) | PRSS1TMPRSS15VCAM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7329837 | 0.83 | PRSS1 (0.63) | PRSS1TMPRSS15VCAM1ALDH1A1GAA | |
| SCHEMBL7331050 | 0.83 | PRSS1 (0.51) | PRSS1TMPRSS15VCAM1ALDH1A1GAA | |
| SCHEMBL6742909 | 0.81 | ALDH1A1 (0.53) | PRSS1ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL7329834 | 0.80 | PRSS1 (0.56) | PRSS1VCAM1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4641784 | 0.80 | ALDH1A1 (0.60) | VCAM1ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL1982730 | 0.79 | TSHR (0.63) | PRSS1ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL7320820 | 0.79 | PRSS1 (0.52) | PRSS1TMPRSS15VCAM1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4570006-A | ANTITHROMBIN; ENZYME AND HORMONE INHIBITORS | TORII & CO. LTD. (JP) | 1986-02-11 | — | — | US | disclosed |
| US-4514416-A | Amidine compound, process for producing same and anti-complement agent comprising same | TORII & CO. LTD. (JP) | 1985-04-30 | — | — | US | disclosed |